HIV Infection and Fracture Risk

A large case-control study conducted in a Northern European population showed an elevated fracture risk similar to that previously demonstrated in primarily North American populations.

HIV- and antiretroviral therapy–induced bone loss has long been recognized, but only recently have we begun to appreciate its effect on fracture risk. In a recent case-control study conducted to explore this association, researchers used Danish National Health Service registries data on patients with fractures in 2000 and age- and sex-matched controls without fractures that year (n=124,655 and 373,962, respectively).

After adjustment for traditional osteoporosis risks, HIV infection was associated with a significantly increased fracture risk (odds ratio, 2.00). This association was particularly strong at key fracture-prone sites, including the hip (OR, 6.46), the spine (OR, 4.65), and the forearm (OR, 2.34). The findings were similar between…

Reviewing Author

Igho Ofotokun, MD, MSc

HIV Infection and Fracture Risk

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Reviewing Author