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The genetic basis of serrated polyposis syndrome (SPS) is not yet understood, and therefore the World Health Organization definition of serrated polyposis cannot be validated. Several previous studies have suggested a high risk for colorectal cancer when patients with serrated polyposis are first recognized and during colonoscopic follow-up.
The current prospective study involved 50 patients with SPS who underwent annual colonoscopy between 2007 and 2012. All polyps ≥3 mm in size were removed. At a median follow-up time of 3.1 years, no colorectal cancers were detected. The risks for detecting colorectal cancer, advanced adenomas, and large (≥10 mm) serrated polyps after three surveillance colonoscopies were 0%, 9%, and 34%. Twelve patients …