Changing Patterns in Causes of Death After ART Initiation

Deaths from AIDS-related causes decreased, while those from non-AIDS cancers increased, with persistent effects of CD4-cell count and viral suppression on mortality patterns.

The introduction of effective antiretroviral therapy (ART) has dramatically decreased AIDS-related mortality, thereby increasing life expectancy and rates of death from non-AIDS conditions (e.g., non-AIDS cancers, liver disease, cardiovascular disease) among HIV-infected individuals. In a recent study involving 16 cohorts in Europe and North America, researchers assessed the changes in patterns of death over time following ART initiation.

Eligibility requirements included age ≥16, no previous ART exposure, initiation of an ART regimen that included ≥3 drugs, and follow-up between 1996 and 2009. Information was collected on patient demographics, transmission-risk group, and clinical characteristics, with a focus on causes of death and key tim…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Changing Patterns in Causes of Death After ART Initiation

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Reviewing Author