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Behavioral and pharmacological interventions can induce weight loss in obese adults, but whether such interventions help maintain weight loss is unclear. In this systematic review and meta-analysis of 45 randomized trials, investigators assessed the effectiveness of nonsurgical interventions for long-term weight-loss maintenance in 7800 obese adults.
Behavioral interventions that focused on both food intake and physical activity blunted the average amount of regained weight by 1.6 kg at 12 months and by 2.0 kg at 18 months, compared with control (or no) interventions. Orlistat (Alli, Xenical) combined with behavioral interventions prevented an average of 1.8 kg of weight regain at 12 months; 120 mg thrice daily was more effective than 60 mg …