Obstructive Sleep Apnea, Obesity, and Cardiovascular Risk Factors

Researchers tease out the relative effects of weight reduction and continuous positive airway pressure in obese patients with OSA.

Obstructive sleep apnea (OSA) and obesity are related to each other, and both conditions are associated with atherosclerotic risk factors. In this study, researchers sought to determine the relative contributions of weight loss and continuous positive airway pressure (CPAP) to improvement in risk factors in 181 patients with obesity (body-mass index, >30 kg/m²), moderate-to-severe OSA, and serum C-reactive protein level >1.0 mg/L (median, ≈4.5 mg/L).

Patients were randomized to an intensive weight-loss program, CPAP, or both. At 24 weeks, mean decrease in weight was 7 kg in the weight-loss and combined-intervention groups, and none in the CPAP-only group. In an intent-to-treat analysis at 24 weeks, average CRP levels (the primary endpoint) d…

Reviewing Author

Allan S. Brett, MD

Disclosures

Nothing to disclose

Allan S. Brett, MD

Disclosures

Nothing to disclose

Obstructive Sleep Apnea, Obesity, and Cardiovascular Risk Factors

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Reviewing Author