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The body's responses to repetitive hypoxemia and reoxygenation presumably are responsible for some adverse cardiovascular effects of obstructive sleep apnea (OSA). Thus, provision of supplemental oxygen alone, without continuous positive airway pressure (CPAP), might confer some of the cardiovascular benefits of CPAP — including lowering of blood pressure. In this study, U.S. researchers randomized 318 patients with moderate-to-severe OSA and coronary disease or coronary risk factors to receive either CPAP, nocturnal supplemental oxygen (2 L/minute), or neither intervention; all patients received education on healthy lifestyle and sleep hygiene. The primary outcome — 24-hour mean arterial blood pressure (MAP) — was 89 mm Hg at baseline; mos…