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The term “heparin-induced” is in quotes because the variety of heparin-induced thrombocytopenia (HIT) in the current study occurred in two patients not exposed to heparin. These patients presented with the typical HIT clinical syndrome, consisting of thrombocytopenia, thrombosis, and strongly positive serological tests.
To characterize this HIT-mimicking disorder, investigators report detailed clinical and serologic testing in the two patients: a 54-year-old woman and a 62-year-old man, each with a thrombotic stroke and thrombocytopenia (platelet counts, 61 and 65 per μL, respectively), and neither had been exposed to heparin.
Serologic testing revealed 100% serotonin release in the presence of low concentrations of heparin, and no serotonin …