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The interaction between fetal growth restriction and congenital anomalies in determining stillbirth risk is not well understood. In a retrospective, single-center cohort study involving >65,000 pregnancies, researchers analyzed ultrasound data routinely obtained from 1990 to 2009 for identification of fetal anomalies. The final cohort included 873 pregnancies with isolated major congenital anomalies and 64,165 pregnancies without anomalies.
Intrauterine growth restriction (IUGR) was diagnosed at birth in 24.4% of anomalous fetuses and 11.5% of nonanomalous fetuses (P<0.01). Overall stillbirth rates were 55/1000 anomalous fetuses and 4/1000 anatomically normal fetuses (adjusted odds ratio, 15.2); when both a congenital anomaly and growth rest…