Improved School-Age Outcomes Following Moderate Hypothermia for Perinatal Encephalopathy

Therapeutic hypothermia after perinatal asphyxia improves cognitive and motor outcomes in school-age children.

Moderate or severe hypoxic ischemic encephalopathy (HIE) affects up to 1 per 1000 live births and is associated with high mortality and disability rates. At least 25% of survivors have long-term sequelae such as cerebral palsy, and cognitive impairments have been reported in school-age survivors. Several large trials have shown that controlled therapeutic hypothermia for 72 hours improves outcomes during the first 18 to 24 months of life, but whether these improvements are sustained through childhood is uncertain. The U.K. Total Body Hypothermia for Neonatal Encephalopathy Trial (TOBY) randomized 325 newborns with moderate-to-severe HIE to whole-body hypothermia or standard temperature care (NEJM JW Pediatr Adolesc Med Oct 7 2009). Hypother…

Reviewing Author

Robin Steinhorn, MD

Disclosures

Consultant/Advisory BoardActelion Pharmaceuticals

Editorial BoardsJournal of Pediatrics

Leadership Positions in Professional SocietiesAmerican Pediatric Society (President); American Board of Pediatrics (Board of Directors)

Robin Steinhorn, MD

Disclosures

Consultant/Advisory BoardActelion Pharmaceuticals

Editorial BoardsJournal of Pediatrics

Leadership Positions in Professional SocietiesAmerican Pediatric Society (President); American Board of Pediatrics (Board of Directors)

Improved School-Age Outcomes Following Moderate Hypothermia for Perinatal Encephalopathy

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Reviewing Author