Loading...
The specific causes of primary sclerosing cholangitis (PSC) are unknown, as are its associated comorbidities and an effective treatment. The disease likely has a genetic component, and its association with inflammatory bowel disease strongly suggests an immune-mediated component. However, little is known about possible nongenetic lifestyle and environmental factors that influence the development of PSC.
In 2011, all living patients in the Norwegian PSC registry were invited to participate in a questionnaire study. Questionnaire items included dietary habits, comorbidities, lifestyle factors, and workplace exposures. Gender and age–matched control patients were identified from the Bone Marrow Donor Registry.
Of 336 participants invited, 245 co…