Nonsurgical Interventions Prevent Gallstones During Weight Loss

Rapid weight loss is associated with an increased risk for gallstone formation because of cholesterol supersaturation and gallbladder hypomotility. To evaluate the efficacy of nonsurgical treatments to prevent gallstones in obese adults participating in weight loss interventions, investigators conducted a systematic review and meta-analysis.

Thirteen randomized, controlled trials were included in the study and comprised 1836 participants who were obese (body-mass index >30 kg/m²). Eight trials involved dietary weight-loss interventions, and five involved bariatric surgery. Eleven trials assessed administration of ursodeoxycholic acid (UDCA) during diet-based interventions or after bariatric surgery, and two trials assessed a high-fat weight-…