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Although insulin pumps are used widely in managing patients with advanced type 2 diabetes, studies in which pump therapy was compared with multiple daily insulin injections in this population have been small and inconclusive.
In a multinational study sponsored by a pump manufacturer, researchers recruited 495 adults whose type 2 diabetes was poorly controlled despite multiple daily insulin injections. Participants underwent a standardized basal–bolus dose-optimization program for 2 months. A total of 331 patients completed the program with glycosylated hemoglobin (HbA1c) levels between 8.0% and 12.0% (mean, 9.0%) and were randomized to pump therapy or continued multiple daily insulin injections with ongoing dose titration.
At 6 months, mean H…