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Psychogenic nonepileptic seizures (PNES, pseudoseizures) are conversion symptoms involving seizure-like movements in patients with normal electroencephalographic results. In this 4-month study on whether treatment affects PNES frequency, 38 patients with PNES and no epilepsy were randomized to one of four approaches: treatment as usual, sertraline (dose, ≤200 mg/day), 12 weekly sessions of manualized “cognitive-behavioral therapy–informed psychotherapy” (CBT-ip), or CBT-ip plus sertraline.
CBT-ip involved presenting the diagnosis; elements of education, behavioral analysis, cognitive therapy, interpersonal therapy, mindfulness, and dynamic psychotherapy; and teaching coping skills. Data from 34 patients were analyzed.
Both psychotherapy and p…