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A 2008 meta-analysis deepened our understanding of associations among body-mass index (BMI), sex, and incidences of a variety of malignancies (NEJM JW Gen Med Feb 28 2008). Now, using data collected from British general practices, researchers have analyzed >160,000 new cancers that occurred in a population of 5 million people (age, ≥16) during a mean follow-up of 7.5 years. The investigators evaluated the relations between baseline BMI and cancer incidence and the contributions of other factors such as age, smoking, and menopausal status.
Increasing BMI was associated with increasing incidences of cancers of the uterus, gallbladder, kidney, cervix, thyroid, liver, colon, ovary, and breast (postmenopausal) and with leukemia. Overall, cancers …