Effect of Quadrivalent Conjugate and Serogroup B Meningococcal Vaccines on Pharyngeal Carriage

Both preparations reduced meningococcal carriage during follow-up — the quadrivalent vaccine against vaccine serogroups, and the serogroup B vaccine more broadly.

Meningococcal conjugate vaccines protect those vaccinated; they can also prevent carriage and thereby provide herd immunity. In a manufacturer-supported, phase 3, randomized trial, investigators assessed the effects of a quadrivalent glycoconjugate vaccine targeting serogroups A, C, Y, and W (MenACWY-CRM) and a multicomponent serogroup B meningococcal vaccine (4CMenB) on meningococcal carriage rates.

Healthy students aged 18 to 24 in England were randomized in a 1:1:1 ratio to receive two doses of 4CMenB, one dose of MenACWY-CRM followed by one dose of placebo, or — as a control — two doses of Japanese encephalitis vaccine. Doses were given 1 month apart. Oropharyngeal cultures were obtained before vaccination and for 12 months after the fir…

Reviewing Author

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Effect of Quadrivalent Conjugate and Serogroup B Meningococcal Vaccines on Pharyngeal Carriage

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Reviewing Author