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Use of antiepileptic drugs during pregnancy has been associated with pregnancy complications (NEJM JW Womens Health Jul 28 2011) and fetal malformations (NEJM JW Womens Health Jul 14 2011). To investigate the association between exposure to antiepileptic drugs during pregnancy and risk for miscarriage, investigators in Denmark used national registries to conduct a population-based cohort study of 983,305 pregnancies from 1997 through 2008.
Antiepileptic drugs were used in 4700 pregnancies. Analyses adjusted for maternal age and comorbidities showed that women who took antiepileptic drugs during early pregnancy were no more likely to miscarry than women who were exposed to these drugs during the year before conception but not during pregnancy…