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To address concerns about adverse effects of antipsychotic drugs (e.g., NEJM JW Psychiatry Sep 29 2008), these researchers correlated 10 years of Danish registry data on all out-of-hospital cardiac arrests (OHCAs), all prescriptions, and inpatient and outpatient treatment.
In 28,947 people with OHCA, 2205 were taking at least one antipsychotic drug (median age, 66). The risk for OHCA was significantly increased with any antipsychotic (odds ratio, 1.53). Typical antipsychotics as a class were associated with an increased OHCA risk (OR, 1.66), but atypical antipsychotics were not. In analyses of 11 individual medications, greater OHCA risk was associated with the atypical quetiapine (OR, 3.64) and the neuroleptics haloperidol (OR, 2.43) and le…