Is Midodrine Effective for Orthostatic Hypotension and Recurrent Reflex Syncope?

Midodrine is an option to treat orthostatic hypotension and reflex syncope but may lack evidence to consider it a first-line treatment.

This systematic review was performed to evaluate the efficacy and safety of midodrine in patients with symptomatic orthostatic hypotension (SOH) — defined as a fall in systolic blood pressure of at least 20 mm Hg or diastolic blood pressure of at least 10 mm Hg within 3 minutes upon standing — and recurrent reflex syncope (RRS). To identify trials of patients with SOH or RRS that compared treatment with midodrine against controls, researchers performed a search of multiple electronic databases without language restriction from the databases' inception to June 2013.

Eleven trials involving a total of 593 patients were included in the review. Three studies showed improvement in health-related quality of life in patients with RRS receiving mido…

Reviewing Author

Jaime Toro, MD

Disclosures

Editorial BoardsMultiple Sclerosis and Related Disorders

Jaime Toro, MD

Disclosures

Editorial BoardsMultiple Sclerosis and Related Disorders

Is Midodrine Effective for Orthostatic Hypotension and Recurrent Reflex Syncope?

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Reviewing Author