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Increasing resistance to clarithromycin and metronidazole is decreasing response rates to Helicobacter pylori treatment throughout the world. Multiple approaches have been suggested to treat patients who have failed initial therapy.
Investigators in China retrospectively assessed treatment success in 109 consecutive patients who had previously failed standard triple therapy and were subsequently treated for 14 days with rabeprazole (20 mg), tetracycline (750 mg), furazolidone (100 mg), and colloidal bismuth subcitrate (200 mg), all twice daily. H. pylori infection was assessed using a breath test at least 4 weeks after the end of treatment.
Successful eradication was achieved in 100 patients (91.7%) in the intention-to-treat-analysis. Adverse…