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Although the Apgar score was not originally designed as a prediction tool, analyses of large birth cohorts have indicated increased neonatal mortality in association with lower 5-minute Apgar scores. To clarify the causes of such infant death, investigators in Scotland linked national discharge and mortality data for some 1 million singleton live births between 1992 and 2010.
Overall, low 5-minute Apgar scores (range, 0–3) were associated with increased risk for neonatal and infant death: Adjusted relative risk was 359.4 for neonatal death before 7 days, 30.5 for neonatal death between 7 and 28 days, and 50.2 for infant death before 1 year. This association was strongest for babies born at term, and deaths were attributed primarily to anoxia…