Predicting Thrombosis in Relatives of Patients with Venous Thromboembolism

Unprovoked VTE and VTE at young age are among factors associated with increased risk for family members.

A family history of venous thromboembolism (VTE) increases the likelihood that a patient might have this disorder, but the degree of risk seems quite variable. To identify factors associated with a familial tendency toward VTE, investigators in Canada and France examined 915 first-degree relatives of 138 patients with provoked VTE (occurring within 3 months of major surgery, major leg trauma, immobilization, or with cancer) and 1916 first-degree relatives of 378 patients with unprovoked VTE.

Results were as follows:

The incidence of VTE was higher in relatives of index cases with unprovoked VTE than in relatives of index cases with provoked VTE (odds ratio, 2.38; 95% confidence interval, 1.43–3.85).
Risk for VTE in relatives was associated wit…

Reviewing Author

David Green, MD, PhD

Disclosures

EquityNovartis

David Green, MD, PhD

Disclosures

EquityNovartis

Predicting Thrombosis in Relatives of Patients with Venous Thromboembolism

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Reviewing Author