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Fish oil has been touted for its many benefits, including reductions in inflammation and oxidative stress. Some investigators have hypothesized that these reductions would lead to reduced atrial fibrillation (AF) burden; previous studies have yielded mixed results. In a well-designed, Canadian, double-blind, controlled trial (NCT01235130), researchers randomized 337 patients with paroxysmal or persistent AF to 4 g of omega-3 fatty acids daily or to placebo.
The primary outcome was recurrence of symptomatic AF (documented by 12-lead electrocardiography, transtelephonic monitoring strips, or implanted devices), or asymptomatic AF lasting >30 seconds (measured by weekly transtelephonic monitors). After a mean follow-up of 270 days, fish oil was…