Sepsis Bundle Compliance Is Associated with Improved Survival

The Surviving Sepsis Campaign (SSC) has led to early identification and treatment of patients with sepsis. Using the SSC's database, investigators analyzed the association between compliance with resuscitation and management bundles and mortality at 218 community, academic, and tertiary care hospitals in the U.S., Europe, and South America. The study included 29,470 patients who met criteria for severe sepsis and septic shock over 7.5 years.

Each hospital was categorized as high or low compliance based on whether the percentage of patients who achieved all bundle elements was higher or lower than the median for all study hospitals (medians were 15% for the resuscitation bundle and 20% for the management bundle). Mortality was lower at hospit…