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Relapse of Clostridium difficile infection after antibiotic treatment with metronidazole or vancomycin occurs in 20% to 30% of patients. Patients with multiple relapses have a risk for additional relapse of up to 60% and become candidates for fecal microbiota transplantation (FMT); this is usually accomplished by colonoscopy in the U.S. but has also been achieved by administration of feces by enema, nasogastric tube, and upper endoscopy, and with frozen encapsulated feces.
In the current uncontrolled study, researchers assessed the feasibility of FMT by oral administration of frozen, capsulized feces in 20 patients with refractory or recurrent C. difficile infection. The four donors were unrelated to patients.
Patients discontinued antibiotic…