CD30⁺ Lymphoproliferative Disorders: An Expanding and Versatile Group of Lymphomas

CD30⁺ T-cell lymphoproliferative disorders (TLPDs) include anaplastic large cell lymphoma (ALCL) and lymphomatoid papulosis (LyP). Because their morphologies overlap, some cases need follow-up to properly subclassify the tumors. Recently, CD30⁺ TLPDs with intravascular involvement have been described. These authors retrospectively studied 18 cases of cutaneous intravascular large cell lymphoproliferations.

They included nine CD30⁺ TLPDs (5 ALK⁻ ALCLs), one ALK⁺ ALCL, six B-cell lymphomas, and two benign microscopic intravascular T-cell proliferations. Twelve were lymphoproliferative. Median patient age was 70, and lesion location varied. The ALK⁻ ALCLs presented as plaques, and the ALK⁺ ALCL as peau-d'orange.

Of the nine patients with ALK⁻ CD…