Encapsulated Benzoyl Peroxide for Rosacea

Two gel formulations reduced the number of inflammatory papules, but vehicle alone was effective too.

Two recent studies have shown that a combination benzoyl peroxide/clindamycin product successfully treated papulopustular rosacea. To test the efficacy of encapsulated benzoyl peroxide (E-BPO) alone, researchers enrolled 92 subjects with papulopustular rosacea in a multicenter, phase II, randomized, double-blind, vehicle-controlled, parallel-group comparison of E-BPO 5% gel, E-BPO 1% gel, or vehicle.

Most subjects (74%) had moderate disease with at least 12 inflammatory papules at baseline. Patients applied gel once daily for 12 weeks and were evaluated at 4, 8, and 12 weeks. Both E-BPO gels significantly reduced the numbers of inflammatory papules (median reduction, 10 with vehicle, 12.5 with 1% E-BPO [P=0.0123], and 15 with 5% E-BPO P=0.02…

Reviewing Author

Mark V. Dahl, MD

Disclosures

Consultant / Advisory board Ulthera, Inc.; AuBio LifeSciences, LLC; Paris Therapeutics

Equity Elorac, Inc.; Makucell, Inc.; Paris Therapeutics

Editorial boards UpToDate

Leadership positions in professional societiesNational Rosacea Society (Chairman, Medical Board)