Myofibromas with Atypical Features: What Does It Mean?

Myofibromas, benign proliferations of myofibroblasts, can present as solitary or multicentric lesions in children and young adults. Histology often shows a classic presentation — biphasic tumors with a pericytic pattern in the central zone and a periphery of myoid nodules — but atypical features are possible. Myofibromas themselves have an excellent prognosis, but they can lead to death if multiple tumors compromise vital organs. These authors analyzed the significance for patient outcome of atypical findings.

The researchers reviewed 24 myofibroma cases in which the pathology report identified one or more atypical features: hypercellularity, absent or inconspicuous myoid nodules, infiltrative borders, or perineural or intravascular invasion…