Preadmission NSAIDs and Stroke Mortality: Is There a Link?

A case-control study suggests an association.

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is widespread in the general population. In some pharmacologic studies, NSAIDs can interfere with the antiplatelet effects of aspirin and potentially blunt the vascular protection offered by aspirin. Whether NSAID use prior to a stroke affects stroke mortality is unclear.

These authors evaluated 100,043 incident strokes registered in Denmark during a 9-year period. The investigators categorized NSAID use as current (prescription filled in the previous 60 days), former use (within 180 days), or nonuse, and computed hazard ratios for death within 30 days after an ischemic or hemorrhagic stroke according to medication use category. The authors evaluated specific NSAIDS, including the cate…

Reviewing Author

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Preadmission NSAIDs and Stroke Mortality: Is There a Link?

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Reviewing Author