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Family history is a risk factor commonly used in advising at-risk patients — particularly those with inherited syndromes such as Lynch — regarding colorectal cancer screening. Would personalized risk counseling increase adherence to screening recommendations?
To address that question, investigators randomized 738 participants to undergo genetic and environmental risk assessment or usual care. Participants were aged 50 to 79 years, at average risk for colorectal cancer, and asymptomatic. They had not had fecal occult blood testing in the past 12 months, barium enema or flexible sigmoidoscopy in the past 5 years, or colonoscopy in the past 10 years. In the risk-assessment group, patients were assigned to meet with a study nurse, discuss the ge…