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Genetic factors, such as APOE alleles, that place individuals at increased risk for Alzheimer disease and for poor episodic memory performance in the context of aging are well known. Less is known about genetic factors that may lead to excellent memory performance in elders. Familial aggregation of exceptional episodic memory (EEM) has been reported in the Long Life Family Study (LLFS). To explore this finding in more detail, researchers performed a genome-wide linkage in 18 EEM families from LLFS (467 individuals) and followed up with single-nucleotide polymorphism (SNP) analysis using episodic memory scores (mean of standardized Logical Memory IA and IIA) in four independent, well-characterized elderly cohorts without dementia (n=4006).
A …