Treatment for Cervical Intraepithelial Neoplasia Does Not Impair Subsequent Fertility

However, CIN treatment may raise risk for second-trimester miscarriages, ectopic pregnancies, and elective terminations.

Although treatment of cervical intraepithelial neoplasia (CIN) — and perhaps CIN itself — may have detrimental effects on obstetric outcomes (excess risk for perinatal death, preterm delivery, and low birth weight), few efforts have evaluated the effects of such treatment on fertility and early pregnancy outcomes. In a systematic review and meta-analysis, researchers identified 15 observational studies addressing the issue of fertility.

Although heterogeneity among the studies was pronounced, the meta-analysis showed no evidence that any modality of treatment for CIN adversely affected the chances of conception. However, pooled analysis of eight studies suggested that risk for second-trimester miscarriage was increased (1.6% vs. 0.4% for unt…

Reviewing Author

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Treatment for Cervical Intraepithelial Neoplasia Does Not Impair Subsequent Fertility

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Reviewing Author