Should Moderate MR Be Repaired During CABG?

Although a combined procedure may improve mitral regurgitation, other measures were not as positive.

The potential benefit of adding mitral valve repair (MVR) to coronary artery bypass grafting (CABG) in patients with moderate mitral regurgitation (MR) is uncertain. In this multicenter trial (NCT00806988), 301 patients with ischemic moderate MR (inclusion criterion for effective regurgitant orifice area [EROA], 0.2–0.4 cm²) were randomized to CABG plus MVR or to CABG alone (mean age, 65; men, 68%; left ventricular [LV] ejection fraction, ~40%). The primary endpoint, an echocardiographic measure of reverse LV remodeling, was LV end-systolic volume index (ESVI) at 12 months.

The mean EROA was 0.2 cm² in both groups. Mean LVESVI at 12 months was similar in the two groups, with a mean decrease of 9 mL/m². The groups showed no significant differ…

Reviewing Author

Howard C. Herrmann, MD

Disclosures

Consultant/Advisory BoardAffluent Medical; Artedrone; Caranx; Johnson & Johnson; Medtronic; Prolifagen; Wells Fargo

EquityMicrointerventional Devices, Inc.

RoyaltiesUniversity of Pennsylvania

Grant/Research SupportAbbott Vascular; Edwards Lifesciences; Johnson & Johnson; Medtronic

Editorial BoardsCatheterization and Cardiovascular Interventions; Journal of the American College of Cardiology; Circulation: Cardiovascular Interventions; JACC Cardiovascular Interventions; JACC Case Reports; JSCAI

Leadership Positions in Professional SocietiesHeart Valve Collaboratory (Scientific Committee Member, Chair of the Publications Committee)