TRT in HIV-Infected Men: The Need for Better Monitoring

Data from a large multicenter cohort showed that testosterone-replacement therapy was commonly prescribed — often without pretreatment testing or posttreatment monitoring.

Prescription androgen use in the U.S. tripled between 2001 and 2011, by which time nearly 3% of men aged >40 were on testosterone replacement therapy (TRT). Researchers from the Centers for AIDS Research Network of Integrated Clinical Systems used data collected in seven HIV clinics between 1996 and 2011 to characterize TRT initiation and monitoring in HIV-infected men without evidence of prior testosterone use.

During 75,173 person-years of follow-up, TRT was initiated in 1482 of the 14,454 study participants (19.7/1000 person-years of follow-up, vs. 7.57/1000 person-years in the general population). In a multivariate model, factors significantly associated with TRT initiation were age ≥35, white race, diagnosis of AIDS wasting, hepatitis C…

Reviewing Author

Charles Hicks, MD

Disclosures

Consultant / Advisory boardGilead Sciences; ViiV; Merck

RoyaltiesUpToDate, Inc.

Grant / Research supportNIH; Department of Health and Human Services

Charles Hicks, MD

Disclosures

Consultant / Advisory boardGilead Sciences; ViiV; Merck

RoyaltiesUpToDate, Inc.

Grant / Research supportNIH; Department of Health and Human Services

TRT in HIV-Infected Men: The Need for Better Monitoring

Topics

Reviewing Author