Studies Suggest We Should Modify Our Approach to Sepsis Treatment

Early goal-directed therapy and a liberal transfusion threshold did not benefit critically ill septic patients.

In 2014, three long-awaited, randomized trials of treatment in patients with septic shock were released, and the third involved transfusion threshold in this population.

Two studies focused on the early resuscitation of patients with septic shock. In the PROCESS trial, 1341 patients with septic shock received one of three treatment strategies: early goal-directed therapy (EGDT) with specific targets for central venous pressure, central venous saturation, and hematocrit; protocol-based resuscitation with peripheral access only and slightly different hemodynamic targets; or usual care. No difference in 60-day, 90-day, or 1-year mortality was noted between groups (NEJM JW Emerg Med Mar 18 2014). In the ARISE trial, 1600 septic shock patients re…

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Patricia Kritek, MD

Disclosures

Editorial BoardsATS Scholar

Patricia Kritek, MD

Disclosures

Editorial BoardsATS Scholar

Studies Suggest We Should Modify Our Approach to Sepsis Treatment

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