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Life expectancy in patients with schizophrenia is 10 to 20 years shorter than in people without schizophrenia and of similar age and sex. Some studies suggest that this is partly attributable to the adverse cardiovascular effects of antipsychotic medications, but detailed understanding is lacking. Studying Swedish national registries from 2006 through 2010, investigators examined cumulative antipsychotic exposure in relation to all-cause and disease-specific mortality in two cohorts of patients with schizophrenia (age range, 17–65) — 21,492 patients diagnosed before 2006 (“chronic”), and 1230 patients initially diagnosed between 2006 and 2010 (“first-episode”). Data on 214,670 and 12,110 matched general-population controls, respectively, we…