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Pulmonary infection with nontuberculous Mycobacterium avium complex (MAC) invariably requires long-term treatment with multiple drugs. In an effort to prevent the serious drug side effects that often complicate these regimens, clinical guidelines endorse intermittent rather than daily therapy for patients without cavitary disease. However, the evidence behind this recommendation is acknowledged to be quite poor. In this retrospective study, investigators reviewed treatment outcomes among 217 treatment-naive patients with noncavitary MAC pulmonary infection who were seen at a single South Korean hospital between 2005 and 2012. The 99 patients who began treatment before 2011 received daily therapy with three standard drugs (a macrolide, a rif…