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In high-risk patients, aspirin is highly effective and safe for the prevention of coronary disease. In patients with low cardiovascular disease (CVD) risk, the use of aspirin is associated with increased morbidity, including intestinal bleeding and hemorrhagic strokes. Using data from the National Cardiovascular Disease Registry's Practice Innovation and Clinical Excellence registry, researchers ascertained the inappropriate use of aspirin in primary prevention in 68,808 patients from 119 practices in the U.S. The use of aspirin was considered appropriate when the CVD risk was ≥6% in 10 years and inappropriate when <6%.
Compared with those with appropriate aspirin use, patients who were inappropriately prescribed aspirin were younger (49.9 v…