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Anticoagulants, antiplatelet drugs, and nonsteroidal anti-inflammatory drugs (NSAIDs) are all associated with an increased risk for gastrointestinal bleeding (GIB). To compare the risks for bleeding between these drug classes, investigators prospectively collected data on 1008 patients hospitalized with GIB (upper tract, 563; lower tract, 415; undetermined location, 30) from several hospitals in Spain. These patients were matched to 1008 unhospitalized controls. Investigators examined participants' exposure to any drug within the 7 days prior to the bleeding episode.
In logistic regression analysis, exposure to anticoagulants, low-dose aspirin, non-aspirin antiplatelet drugs, or NSAIDs was associated with elevated risk for upper GIB (adjuste…