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The concept of the “tipping point” — i.e., having fewer new HIV infections than individuals initiating antiretroviral therapy (ART) — is a measure of HIV control used by the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) and other organizations. The “tipping point ratio” is defined as the annual number of new infections divided by the number of individuals initiating ART (or, alternatively, achieving viral suppression) within a given jurisdiction.
To determine tipping point ratios in the U.S., investigators used surveillance data from 10 jurisdictions with complete reporting of all viral load data through 2012. They focused on patients with a new HIV diagnosis in 2011 and those who newly achieved viral suppression (i.e., viral load…