How Do Congenital Uterine Anomalies Affect Reproductive Outcomes?

Effects varied among different abnormalities; whether to remove uterine septa before pregnancy is attempted remains controversial.

Congenital uterine anomalies (CUA) are relatively common, yet we know little about their effects on reproductive and obstetric outcomes. European investigators conducted a meta-analysis of 21 retrospective and 4 prospective comparative studies (3477 patients) in which outcomes were assessed in women with anomalous or normal uteri.

Probability of spontaneous pregnancy was lower than normal only in women with septate uteri (relative risk, 0.86; 95% confidence interval, 0.77–0.96), and probability of pregnancy with assisted reproductive technology was unaffected by any anomaly. Risk for first- or second-trimester miscarriage was significantly higher in women with septate (RR, 2.81), bicornuate (RR, 2.40), or unicornuate (RR, 2.10) uteri. Risk f…

Reviewing Author

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

How Do Congenital Uterine Anomalies Affect Reproductive Outcomes?

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Reviewing Author