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Many genetic variants have been identified that individually are associated with excess risk for coronary heart disease (CHD). Researchers combined 27 of these markers into a composite risk score and then assessed the association of this score with CHD events among more than 27,000 patients (categorized by score quintiles) in an epidemiologic cohort. Using the same quintile system, the researchers also assessed CHD events and response to statin therapy among more than 17,000 patients in two primary and two secondary prevention trials.
After adjustment for standard risk factors across all five studies, relative risk for CHD among patients in the middle three genetic-risk quintiles (i.e., those at intermediate risk) was 1.34, and risk for thos…