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Cephalosporins are widely used for treating outpatient and inpatient infections and for surgical prophylaxis. Researchers sought to examine the safety of cephalosporins.
A retrospective review of all patient charts in the Kaiser Permanente Southern California healthcare system identified 820,000 patients who received 1.4 million courses of cephalosporins in outpatient, e-visit, or inpatient settings from 2010 through 2012. Almost 66,000 patients who received cephalosporins had previously documented allergies to penicillin, and 3300 had previous reports of cephalosporin allergies. New reports of allergies to cephalosporins were entered for 0.56% of women and 0.43% of men.
Only 13 patients met criteria for anaphylaxis, 3 met criteria for severe…