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About 1.6 million breast biopsies are performed in the U.S. each year. Although criteria for interpreting the results of a breast biopsy are well established, the extent to which pathologists agree on the final diagnosis is unclear.
To investigate potential observer variability and potential ambiguity in breast disease and cancer diagnoses, investigators sent 60 breast biopsy slides — with a diagnosis unanimously agreed upon by three expert breast pathologists — to 115 practicing pathologists in eight states with at least 1 year of experience. Most of the participants (93%) reported confidence in interpreting breast pathology.
Overall concordance of diagnosis between the participants and expert pathologists was 75.3%. Concordance by diagnosis…