It was accelerated in patients with moderate-to-severe TBI but not in those with mild TBI.
Traumatic brain injury (TBI) can cause permanent structural and functional changes in the brain and increase the risk for dementia. To determine whether TBI might also accelerate the aging process of the brain, investigators created a neuroimaging model of normal brain aging and applied it to TBI patients.
The model, which used magnetic resonance imaging (MRI)–derived estimates of gray and white matter, accurately predicted brain age in a model-development cohort of 1537 healthy individuals. Researchers then applied the model to MRI images of 99 TBI patients (mean age, 38; 73% men) and a comparison group of 113 healthy individuals. Contusions on MRI were present in 52 patients, and 82 had moderate-to-severe TBI. Although the time between TBI…
Reviewing Author
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)