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Shorter height is associated clinically with increased risk for coronary artery disease (CAD). To help delineate the possible mechanism of this relationship, researchers used a genetics approach to investigate the association between height and CAD in 65,066 people with CAD (73.8% men) and 128,383 controls (49.8% men). The investigators analyzed 180 previously identified height-associated single nucleotide polymorphisms (SNPs) in the study participants. The average age of participants was 57.3 years. Mean heights in the sample were not reported.
In a meta-analysis that looked at individual subject effects, height-associated SNPs were significantly associated with CAD. Each standard-deviation equivalent of 2.6 inches (6.5 cm) of genetically d…