Sepsis-Associated Multiple Organ Dysfunction: Four Distinct Clusters

The clusters — shock with elevated creatinine, minimal multiorgan dysfunction syndrome, shock with hypoxemia and altered mental status, and hepatic disease — have different outcomes and predictors.

Severe sepsis is defined as suspected or proven infection plus at least two systemic inflammatory response syndrome criteria (temperature >38.0° or <36°C; heart rate >90/min; respiratory rate >20/min or partial pressure of arterial carbon dioxide <32 mm Hg; or white blood cell count >12,000 or <4000/µL) and acute organ failure. In addition to these factors, septic shock requires the presence of persistent hypotension with need for vasopressors. It has not been clear whether the organ failures in severe sepsis and septic shock occur in characteristic clusters.

A retrospective study involving 2533 patients with severe sepsis or septic shock at three hospitals in Utah (overall mortality, 17% ; mean Acute Physiology and Chronic Health Evaluation…

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Sepsis-Associated Multiple Organ Dysfunction: Four Distinct Clusters

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Reviewing Author