Curing Hodgkin Lymphoma Without Radiotherapy

Of patients with stage IA or IIA disease, 89% were cured without radiotherapy after 3 cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine.

The highest priority in Hodgkin lymphoma (HL) is to maintain very high cure rates while minimizing early or late treatment–related toxicity and mortality. To investigate a positron-emission tomography (PET)–response–adapted approach to treatment de-escalation, UK investigators conducted a multicenter, noninferiority phase III trial involving 571 evaluable patients with newly diagnosed stage IA or IIA HL.

Following 3 cycles of standard ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine), PET imaging was performed and evaluated by central review. A total of 426 PET-negative patients (74.6%) were randomized to no further therapy versus the administration of involved-field radiotherapy (RT; 30 Gy). PET-positive patients received a fourth cyc…

Reviewing Author

Michael E. Williams, MD, ScM

Disclosures

Consultant/Advisory BoardAbbVie; AstraZeneca; Beigene; Janssen; Pharmacyclics

Grant/Research SupportJanssen

Editorial BoardsAmerican Board of Internal Medicine (ABIM) Hematology Longitudinal Knowledge Approval Committee

Michael E. Williams, MD, ScM

Disclosures

Consultant/Advisory BoardAbbVie; AstraZeneca; Beigene; Janssen; Pharmacyclics

Grant/Research SupportJanssen

Editorial BoardsAmerican Board of Internal Medicine (ABIM) Hematology Longitudinal Knowledge Approval Committee

Curing Hodgkin Lymphoma Without Radiotherapy

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Reviewing Author