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In 2002, the Diabetes Prevention Program Research Group reported that, in overweight adults with impaired glucose metabolism, lifestyle intervention and metformin lowered the incidence of type 2 diabetes by 58% and 31%, respectively, relative to placebo, during 3 years of follow-up (NEJM JW Gen Med Mar 15 2002 and N Engl J Med 2002; 346:393). Although lifestyle interventions have received considerable attention, little is known about metformin use to prevent diabetes. In this retrospective cohort study, researchers examined health insurance claims data to assess metformin use among >17,000 adults (age range, 19–58) with prediabetes between 2010 and 2012.
During the study, only 3.7% of patients received prescriptions for metformin. Among thos…