Elucidating a Potential Noncontraceptive Benefit of the Copper IUD

Women using copper intrauterine devices (IUDs) may be less likely to develop cervical cancer (NEJM JW Womens Health Nov 2011 and Lancet Oncol 2011; 12:1023). To explore whether copper or levonorgestrel (LNG) IUDs can promote clearance of high-risk HPV infections, researchers in New York City analyzed electronic medical record data from 302 women who received IUDs between 2005 and 2012. Data were excluded if women had histories of HIV or autoimmune disease, immunosuppressive therapy, or treatment for cervical neoplasia.

Among 66 women carrying high-risk HPV before IUD placement, no differences in age, body-mass index, or smoking status were noted by type of IUD. On repeat testing a mean of 1 year after IUD placement, persistent high-risk HPV …