Heparin Should Not Be Used Routinely in Women with Recurrent Miscarriage

But does heparin still have a role in the setting of unrecognized thrombophilias?

Evidence suggests that low-molecular-weight heparin (LMWH) raises live-birth rates in women with thrombophilic disorders and histories of recurrent miscarriage; however, not all thrombophilic disorders can be easily identified. Investigators conducted a randomized, controlled, open-label, multicenter trial of LMWH (5000 IU subcutaneous dalteparin-sodium daily) plus prenatal vitamins versus prenatal vitamins alone in 449 women with at least two prior consecutive early miscarriages (<12 weeks' gestation) or one late miscarriage (≥12 weeks' gestation). Participants with ultrasonographically documented viable pregnancies were enrolled at 5 to 8 weeks' gestation.

Ongoing pregnancy at 24 weeks' gestation was documented in 191 of 220 pregnancies in…

Reviewing Author

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Heparin Should Not Be Used Routinely in Women with Recurrent Miscarriage

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Reviewing Author